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Any activity allowing the exchange of bodily fluids like semen, saliva, blood, or vaginal discharge or when moist skin areas (genitals, mouth, anus) touch is fair game for syphilis transmission.More specifically, you can become infected with syphilis if you [3]: Have unprotected penetrative vaginal, anal, or oral sex Kiss or lick the anus Share unwashed or unprotected sex toys Touch genitals Syphilis spreads from person to person by direct contact with a syphilitic sore, known as a chancre